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Details

Stereochemistry ACHIRAL
Molecular Formula CH4N2O
Molecular Weight 62.0478
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of UREA C-14

SMILES

N[14C](N)=O

InChI

InChIKey=XSQUKJJJFZCRTK-NJFSPNSNSA-N
InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)/i1+2

HIDE SMILES / InChI
Urea C-14 is a urea molecule radiolabelled with a radioactive carbon-14. Urea C-14 Breath Test is indicated for use in the detection of gastric urease as an aid in the diagnosis of H.pylori infection in the human stomach. The test utilizes a liquid scintillation counter for the measurement of CO in breath samples. To detect H.pylori, urea labeled with C is swallowed by the patient. If gastric urease from H.pylori is present, urea is split to form CO and NH at the interface between the gastric epithelium and lumen and CO is absorbed into the blood and exhaled in the breath. Antibiotics, proton pump inhibitors, sucralfate, and bismuth preparations are known to suppress H.pylori. Ingestion of antibiotics or bismuth within 4 weeks and proton pump inhibitors or sucralfate within 2 weeks prior to performing the test may give false negative results.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
PYTEST

Approved Use

PYtest (14C-Urea breath test) is indicated for use in the detection of gastric urease as an aid in the diagnosis of H. pylori infection in the human stomach. The test utilizes a liquid scintillation counter for the measurement of 14CO2 in breath samples.

Launch Date

1997
PubMed

PubMed

TitleDatePubMed
Influence of antidiuretic hormone on peritoneal membrane area and permeability.
1971 Nov
Urea transport in proximal tubule and the descending limb of Henle.
1972 Aug
Enzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase).
1981 Sep 25
Metabolism of methylazoxymethanol acetate in the F344 rat and strain-2 guinea pig and its inhibition by pyrazole and disulfiram.
1984
Arginine Metabolism in Developing Soybean Cotyledons : II. Biosynthesis.
1989 Jun
Name Type Language
UREA C-14
Common Name English
UREA 14 C
WHO-DD  
Common Name English
UREA, C-14
ORANGE BOOK  
Common Name English
UREA-14C
Common Name English
UREA, C-14 [ORANGE BOOK]
Common Name English
CARBON 14 UREA
Common Name English
14C-UREA
Common Name English
CARBON-14 UREA
Common Name English
UREA ((SUP 14)C)
Common Name English
UREA (14C)
Common Name English
Urea 14 C [WHO-DD]
Common Name English
UREA C 14 [USP IMPURITY]
Common Name English
UREA C 14
USP  
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1937
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL985
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
PRIMARY
DRUG BANK
DB09513
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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PUBCHEM
11457650
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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SMS_ID
100000142185
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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CAS
594-05-8
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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NCI_THESAURUS
C47780
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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DRUG CENTRAL
5147
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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FDA UNII
WBZ6M63TEE
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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EVMPD
SUB115823
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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DAILYMED
WBZ6M63TEE
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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RXCUI
253158
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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EPA CompTox
DTXSID701026303
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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LACTMED
Urea C 14
Created by admin on Fri Dec 15 15:42:29 GMT 2023 , Edited by admin on Fri Dec 15 15:42:29 GMT 2023
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